When the Dearly's dalmatians have their first litter of puppies — fifteen in all — everyone is delighted. But their joy is shattered when the pups are kidnapped! The humans don't have a clue as to who the culprit is, but the smartest dogs in London are on the case — and on the trail of the fur-loving Cruella de Vil, who will stop at nothing to have a Dalmatian fur coat!